WELL-BEING AND PREVENTION DAY
After the great success of the last screening campaign, where Theoreo offered over 80 free prevention appointments, we are pleased to announce a new day dedicated entirely to women's health.
Our CEO, Prof. Jacopo Troisi, flanked by Prof. Pierpaolo Cavallo and Dr. Martina Lombardi, scientific head of Theoreo, will hold a short informative seminar on women's cancer prevention.
Following this, Theoreo staff will engage in the free administration of the MEDEA test for screening endometrial cancer, the most common cancer of the female reproductive tract in Western populations, for which, until now, no screening system had been available.
The test, which is rapid, painless and noninvasive, requires the drawing of a single drop of blood using a lancet, similar to measuring blood glucose.
Appointment May 11, 2023 at 4 p.m. at the Council Chamber of the City of Baronissi.
You can also make a reservation at: +39 334 1921903 or by email by contacting firstname.lastname@example.org.
FREE OPENDAY for women's cancer prevention, as part of the CITY OF PONTECAGNANO Faiano's "OLTRE l'8 MARZO" event
We are happy to announce that on 03/27/2023 at our office at 57 Lucania Street, Pontecagnano Faiano, there will be an open day with free examinations, entirely dedicated to women's prevention.
They will be carried out free of charge with prior reservation:
✓ Visit with Dr. Luigi Cremone, a breast surgeon. An appointment for a mammography examination, also free of charge, will also be provided for women who have received doubtful or unfavorable results from the breast evaluation, on a date to be arranged at the office of Diagnostica Cavallo of Drs. Armando and Pierpaolo Cavallo.
✓ Visit with Dr. Valentina Reina, a medical doctor specializing in Aesthetic Medicine, for the prevention and treatment of skin blemishes and skin damage caused by solar radiation.
✓ Nutritional counseling with Dr. Chiara D'Antonio, a nutrition biologist, in which an assessment of the patient's physical and nutritional status will be carried out with the aim of identifying any unhealthy eating habits and re-educating or rehabilitating the patient nutritionally and dietarily.
✓ MEDEA test, an innovative screening system for endometrial cancer, developed by Theoreo srl in collaboration with the G. Pascale Cancer Institute and the University of Salerno. The test consists of taking a single drop of blood by digital puncture. The sample will undergo metabolomic analysis in order to identify patients with the disease early. The above test is dedicated to women over the age of 50.
The event will be sponsored by the Municipality of Pontecagnano Faiano as part of the series "Beyond March 8, Variations on the Theme," in which Theoreo stands at the forefront of offering direct support to the community by taking care of those who have always been its pillars: women.
You can also make reservations by phone: +39 334 1921903 or by email by contacting email@example.com.
We are waiting for you!
Your health, our mission.
Metabolomics in Public Health: new screening methods for endometrial cancer
Our CEO had a talk at the GYNOCARE COST Action Conference, "Bridging the gap between Research and Cure in Rare Gynaecological Cancers: Where do we stand?" held Feb. 17 and 18 at the University of Campania "Luigi Vanvitelli" in Naples.
The conference was in collaboration with European Network for Gynaecological Rare Cancer research: From Concept to Cure.
The invited international speakers,shared insights on recent developments in gynecological rare cancers, focusing on:
- Basic and translational research: present and future
- Clinical trials: designing cures
- Difficult diagnosis: from the classical method to digital pathology
- Pharma-Biotech: the challenges of the 21st century
Theoreo's talk was titled "Development and Validation of a Serum Metabolomic Signature for Endometrial Cancer Screening in Postmenopausal Women."
Local organizers are Professor Francesca Pentimalli of LUM Giuseppe Degennaro University, Professor Antonio Giordano of the University of Siena, Professor Maurizio Guida of the University of Naples Federico II, Professor Renato Franco of the University of Campania "Luigi Vanvitelli"
Metabolomics in Public Health: new screening methods for endometrial cancer
On December 16, 2022, Theoreo in collaboration with prestigious research and treatment institutions will organize the first "Metabolomics in Public Health" conference. This first year has been dedicated to new methods for screening endometrial cancer.
Endometrial cancer represents the most common neoplasm of the female reproductive system, with more than 88,000 diagnoses per year in Europe. Although the prognosis is closely linked to early diagnosis, there is currently no mass screening for early detection of this cancer.
To effectively combat this disease, Theoreo and Hosmotic, two Campania-based companies engaged in scientific research in biotechnology, have joined efforts with authoritative Campania university and clinical institutions including the University of Salerno, the University of Naples Federico II, the IRCCS fondazione "G. Pascale" and the Avellino section of LILT (Lega Italiana per la Lotta ai Tumori) to create a tool that can be used as a secondary prevention tool, thus for population screening.
The free event was attended by numerous experts in the field and was accredited for CME credits for physicians, biologists and pharmacists, chemists and physicists.
At the end a benefit concert offered by AFI (Asoociazione Flautisti Italiani), the proceeds of which were donated to the assozioen ACTO Campania (Association Against Ovarian Cancer)
NEW RESEARCH LABORATORY INAUGURATED
Today we inaugurated the new laboratory of Theoreo where we will converge all our research activities.
A new reality on the territory of Pontecagnano and the Salernitano area (South Italy). A unique center, thanks to which we have the ambition to create a place of excellence in Translational Medicine in the South, in Italy and internationally.
IV CONGRESS OF THE NORMAMERICAN SOCIETY OF METABOLOMICS (MANA)
The MANA (Metabolomics Association of North America) conference, was held Sept. 16-18.
Our CEO Jacopo Troisi (CEO) and Martina Lombardi (CSO) are located together with Prof. Sean Richards and Prof. Steven Symes (the former teaches Biology, the latter Chemistry at the University of Tennessee, Chattanooga) represented Theoreo at this important scientific event.
They presented the results of the latest validation of the Endometrial Carcinoma Screening Test (Medea Project), a noninvasive test to diagnose early this cancer that afflicts more and more women worldwide.
In addition, a poster on the GEMMA study, an international project in which we are involved in the analysis of autism spectrum disorders; one on data on the screening test for fetal malformations called "Mama Test"; one on our work about a unified approach to cancer screening by metabolomic profiling; and discussion on hepatic steatosis and its evolution to hepatocarcinoma.
MAMA TEST VALIDATION FIRST RESULTS PUBLISHED
It is now available online the paper summarizing the results of a long and complex validation trial of the MAMA Test. With support from the New Zealand arm of the SCOPE study led by Prof. Lesley McCowan of Auckalnd University, researchers at Theoreo blindly applied the MAMA Test to a collection of more than 2,000 pregnant women serum samples from New Zealand. The test correctly detected more than 99% of fetal malformations, confirming the MAMA Test as an accurate and noninvasive ally for early prenatal diagnosis.
The results were published in the prestigious journal AJOG - American Journal of Obstetrics and Gynecology. The papeer is freely accessible until 3rd Dec 2022 at this link.
This is a unique volume written by Prof. Jacopo Troisi with contributions from some of the leading experts in metabolomics.
This book is designed for teaching the fundamentals of metabolomics in order to fill the gap related to the absence of a single, comprehensive text.
The book guides the reader step by step through metabolomics experiments, discussing the main current applications and future prospects of this emerging science.
Therefore, it is a valuable read for both experienced researchers interested in delving into the field and students.
18TH INTERNATIONAL CONFERENCE OF THE METABOLOMICS SOCIETY
From June 19 to 23, the 18th International Conference of the Metabolomics Society was held at the Valencia Conference Center, where leading figures in metabolomics attended.
The Theoreo team, along with Professors Steven Symes and Sean Richards from the University of Tennessee, took part in the prestigious event.
Prof. Jacopo Troisi, CEO of Theoreo Srl, gave a plenary presentation on the latest results related to the MEDEA project highlighting how metabolomics represents a new and promising screening tool for early detection of endometrial cancer.
Prof. Steven Symes outlined the GEMMA project, an international research project with a multi-omics approach to study the onset of autism spectrum disorders.
Prof. Sean Richards presented the results on a validation study, carried out at 15 weeks of pregnancy, to screen for fetal malformations.
Dr. Martina Lombardi, researcher at Theoreo Srl, illustrated an Ensemble Machine Learning model based on metabolomic profiling for noninvasive multicancer screening.
III ANNUAL MEETING OF THE GEMMA PROJECT
The third annual meeting of the GEMMA project, held May 19-20 at the EBRIS Foundation, was a valuable opportunity for interdisciplinary exchange that was attended by all partners afferent to the project.
Theoreo was present with an extensive talk, given by Dr. Martina Lombardi, regarding the perspectives of fecal metabolomics in the study and diagnosis of autism spectrum disorders.
The talk received wide interest, demonstrating the continuing commitment of Theoreo researchers to biomedical study.
OUR CEO IN RANKING OF TOP METABOLOMICS EXPERTS
Our CEO Jacopo Troisi cited in the ranking of top experts in Metabolomics according to the prestigious ExpertScape ranking.
In keeping with Healthy Weight Week (Jan 16-22, 2022), congratulations to Prof. Jacopo Troisi Universita degli Studi di Salerno -- Recognized as an Expertscape Expert in Metabolomics.
STEROID HORMONE-PRODUCING BACTERIA UNDERLYING RESISTANCE TO ANDROGENIC DEPRIVATION THERAPY IN PROSTATIC CARINOMA
Prostate cancer is often treated with ADT, a therapy that negativly affects the biosynthesis of androgens by reducing the possibility of cancer cells growing. Despite the consolidated effectiveness of this treatment, sometimes some subjects, even many years after the first episode, show a resumption of tumor growth.
The study just published in the prestigious journal Science shows that this recovery may be due to an imbalance in the intestinal microbiota that allows some bacterial species to complete the biosynthesis of testosterone starting from endogenous precursors. These results, if further confirmed, could open to new perspectives for the treatment of this fearful pathology and to a new paradigm in the unknown of the complex interaction between human health and the intestinal microbiome.
Theoreo srl proudly participated in this important study coordinated by the Oncological Research Institute based in Lugano in Switzerland, which lasted more than 3 years and which engaged several Italian, Swiss, American and British researchers.
IS IT POSSIBLE A FECAL-ORAL TRANSMISSION OF SARS-COV-2?
What if SARS-CoV-2 isn't transmitted exclusively by air?
Our researchers, who have always been involved in the study of human health protection strategies, have collected the numerous evidences that would seem to suggest a possible fecal-oral transmission of the virus. This scenario opens up new and interesting perspectives both from a therapeutic point of view and for emergency management with a view to containing infections.
The results of this survey have been published, in collaboration with prof. Alessio Fasano, professor of pediatric gastroenterology at Harvard University, in the "World Journal of Gastroenterolology" and are freely available at the link:
A NEW PATH FOR SCREENING OF BLADDER CANCER
Our researchers, in collaboration with researchers from the University of Tennessee, have taken another small but stubborn step in the fight against cancer by defining a new metabolomic signature for bladder cancer. This opens up new scenarios for understanding the basic mechanisms of neoplastic transformation and for explaining the aggressiveness of some cancers. The results of this study, just published by the journal Applied Science, also indicate an innovative possibility for a population screening system for this disease that affects over 26,000 people a year in Italy alone.
THEOREO SRL AT THE MICROPHONE OF BIOTECHNOLOGY NEWs
Our CEO guest at the microphones of Biotechnology news. A chat about the present and future of biotechnologies in Italy.
OUR CEO TEACHER OF THE OMICS SCIENCE COURSE AT THE UNIVERSITY OF SALERNO
Our CEO has obtained the position of lecturer for the exercise mode of the Omics Science course at the Department of Chemistry and Biology "A. Zambelli" of the University of Salerno. The course is active as part of the degree course in Biology.
OUR CEO TEACHER OF METABOLOMICS AT THE UNIVERSITY OF SANNIO
Our CEO has obtained the position of lecturer for the Metabolomics course at the Department of Science and Technology of the University of Sannio. The course is active within the degree program in Genetic and Molecular Biotechnology.
INTESTINAL MICROBIOTA: A STOP TO THE DEVELOPMENT OF COLON-RECTUM CANCER DISCOVERED
Our spin-off partnered with Humanitas University in a study that demonstrated, for the first time, that a strain of gut bacteria plays a protective role against the development of colorectal cancer. The results of the research, supported by AIRC - AIRC Foundation for Cancer Research and directed and coordinated by Prof. Maria Rescigno of Humanitas University, were recently published in the journal "Nature Microbiology".
This study lays the foundations to put a stop to the development of colorectal cancer that affects more than 34,000 people every year in Italy alone.
CONGRESSO NAZIONALE DELLA SOCIETÀ ITALIANA DI PSICOPATOLOGIA DELL'ALIMENTAZIONE
Il nostro CEO ha tenuto una presentazione su invito al prestigioso congresso nazionale della SIPA (Società Italiana di Psicopatologia dell'Alimentazione) tenutosi a Torino presso l'aula Magna del Rettorato "Cavallerizza Reale" il 23 e 24 maggio. Il tema di quest'anno è stato: "Stress e disturbi dell'alimnetazione: reti neurali, reti sociali, reti terapeutiche".
L'intervento presentato da Theoreo è stato: "La metabolomica nello studio dell'anoressia nervosa: possibilità e limiti"
"Metabolomics and complex systems in molecular diagnostics" Talk At Salerno University
Theoreo is one of the gemma project's partners
The European Commission has selected the GEMMA project which aims at identifying potential targets able to favor personalized treatment and prevention of Autism Spectrum Disorders. The study will have a budget of € 14.2M.
GEMMA is an innovative scientific research project for the evaluation of interactions between microbiome, metabolome, epigenome and immune response in order to provide new diagnostic and preventive approaches to autism.
Metabolomic profiles in the progression of non alcoholic fatty liver disease
Dr. Mario Masarone, researcher at the University of Salerno presented at the annual meeting of the American Association for the Study of Liver Diseases (AASLD), held in San Francisco (CA, USA) in November 2018 the study: "Metabolomic profiles in the progression of non alcoholic fatty liver disease". Theoreo is contributing to this exciting study designed by prof. Marcello Persico, Associate Professor of Internal Medicine of the University of Salerno and Director of the Unit of Internal Medicine and Hepatology of P.O. G. Da Procida - AOU Sand Giovanni di Dio e Ruggi D'Aragona, aims to understand the impact of genes-environment relationships in the progression of hepatic steatosis.
In the "details" the link for access to the interview of dr. Masarone at the InfomedicaEducation microphones
MAMA Test – Presented at the ICBDSR Annual Meeting in Prague
Femal cancers prevention day
Theoreo will be present on 18 May from 16:00 to 20:00 in Salerno on the waterfront "Trieste" in a day for the prevention of female tumors. At that site it will also be possible to participate in the clinical trial for the validation of the MEDEA Test.
medea-test first paper
The MAMA Test will be presented on 23-27 June at the annual meeting of the Teratology Society in Clearwater, Florida. Our CEO Jacopo Troisi is the only Italian to have won the Travel award for this presentation
medea-test first paper
It is on line on the site of the "Journal of Proteome Research" the first paper describing the MEDEA-Test
mama-test first paper (chromosomal anomalies)
It is on line on the site of the "Metabolomics" journal the first paper describing the MAMA-test
metabolomics summer school 2017
Professors Sean Richards and Steve Symes from the University of Tennessee (USA) are visiting our laboratory to do placental metabolomic experiments on intrauterine growth restriction within the "Metabolomic Summer School 2017"
METABOLOMICS AND ENDOMETRIAL CANCER: THEOREO-LILT COLLABORATION
The Italian League for Fight against Cancer (LILT) selected and founded our project "assessment of the efficacy of the metabolomic approach in the screening of endometrial cancer", on which we will work in cooperation with the LILT section in Avellino
mama test clinical validation trial
Now on-line the description of the clinical trial for the validation of the MAMA Test
tHE MEDEA TEST PATENT DESCRIPTION IS NOW AVAILABLE ON LINE
The WIPO (World Intellectual Property Organization) website has just published on-line the description of the Invention on which the MEDEA Test is based.
Theoreo colloborates on the cd-gemm project
Thanks to the partnership with the EBRIS foundation and with the Mass General Hospital for Children of the Harvard University, Theoreo will be “the last M” of the CD-GEMM (Celiac Disease-Genetic Environmental Microbiome and Metabolomic Study) international study, which aims at comprehending the mechanisms of onset of celiac disease.
the mama test patent description is now available on-line
The WIPO (World Intellectual Property Organization) website has just published on-line the description of the invention on which the MAMA test is based.
Progettiamo il futuro con L'Europa
The EBRIS Foundation will host the conference “Progettiamo il futuro con l'Europa”
Theoreo and SuperQuark
Theoreo Srl hosted at its laboratory of metabolomics the shots of a report for the TV programme “SuperQuark”.