News
BREAKING BARRIERS IN CANCER SCREENING
We are excited to share another great news from the Metabolomics Society conference. This year, our Chief Scientific Officer, Martina Lombardi, presented an extraordinary poster titled 'Breaking Barriers in Cancer Screening: Integrating Metabolomics Profiling and Ensemble Machine Learning for Comprehensive Gender-Specific Cancer Screening.'
Our goal with this project is to revolutionize cancer screening by developing an innovative system that, through the analysis of a single blood sample, can detect various types of tumors. In the specific case presented, we focused on male urogenital tract tumors, and the results were astonishing.
This research requires significant effort and a crucial component of artificial intelligence. Our researchers are tirelessly working to test the system on a broader cohort and further optimize it. Simultaneously, they are developing a similar test for the female urogenital tract.
The current landscape of cancer screening presents several challenges, including the low participation of the target population, often discouraged by the multiplicity of invasive tests. Our aim is to overcome these barriers by offering a single comprehensive, non-invasive test capable of detecting multiple types of tumors. Such a significant step forward could make a difference in many people's lives.
Research is at the heart of everything we do. We firmly support the importance of scientific research in improving health and well-being for all. We want to express our gratitude to Martina Lombardi and all the researchers tirelessly working on this groundbreaking project.
We will continue to invest resources and effort in research, with the goal of making significant progress in the fight against cancer. A better future for everyone's health is within our reach.
24-June-2023
METABOLOMICS SOCIETY ANNUAL MEETING 2023
The time has finally come for the annual meeting with colleagues from around the world at the prestigious Metabolomics Society conference, held this year in Canada at the Niagara Falls Convention Centre.
Once again, Theoreo took center stage with an extraordinary presentation by Prof. Jacopo Troisi on the remarkable potential of Metabolomics profiling in screening for fetal malformations.
The evidence presented by Prof. Troisi is the result of a decade of in-depth studies involving approximately 3000 pregnant women, engaging researchers and hospitals both in Italy and New Zealand. These studies provide solid support for the use of metabolomics in screening for fetal malformations, and what's even more fascinating is that maternal biochemical response has been consistent regardless of the type of fetal malformation.
The presentation has sparked immense interest, and we are deeply proud of it. We firmly believe that supporting scientific research is crucial, as only through continuous progress can we improve our understanding of the mechanisms underlying human pathologies and offer new solutions to clinical practice.
We would like to express sincere thanks to Prof. Jacopo Troisi for his extraordinary commitment and dedication, as well as to all the researchers who have contributed to this important project. We will continue to work together to promote the well-being of mothers and children worldwide.
13-June-2023
WELL-BEING AND PREVENTION DAY
A new appointment of the "Wellness Days" organized by Theoreo, this time at the Municipality of Battipaglia. We started the day with a brief informative seminar on female oncological prevention, led by Prof. Jacopo Troisi, CEO of Theoreo, Prof. Pierpaolo Cavallo, and Dr. Vera Abenante, Lab Manager of Theoreo. The seminar attracted a large audience and sparked great interest among the attendees.
Subsequently, we offered about 200 MEDEA tests for endometrial carcinoma screening free of charge to the women of the area who decided to participate in the study, entrusting themselves to scientific progress and becoming active participants.
We want to sincerely thank the municipal administration of the Municipality of Battipaglia, especially Mayor Dr. Cecilia Francese, for enthusiastically and sensitively welcoming our project.
A heartfelt thanks goes to the Inner Wheel of Battipaglia for their valuable logistical support and generous donation to research. Your dedication is an example for all of us. đź’™
Finally, thanks to the entire Theoreo team, now composed of 14 young doctors, researchers, and interns, who made this extraordinary day possible by bringing professionalism and expertise to the table. Behind every success, study, conference, and analysis, there is the commitment of a staff made up of people with hearts as big as their talents, which makes this reality not just a company, but a winning team. 🙏
Thanks to all who participated and made this day unforgettable. Your enthusiasm and support drive us to continue fighting for a healthier and happier future. Together, we can make a difference! ✨
10-June-2023
WELL-BEING AND PREVENTION DAY
After the great success of the last screening campaign, where Theoreo offered over 80 free prevention appointments, we are pleased to announce a new day dedicated entirely to women's health.
Our CEO, Prof. Jacopo Troisi, flanked by Prof. Pierpaolo Cavallo and Dr. Martina Lombardi, scientific head of Theoreo, will hold a short informative seminar on women's cancer prevention.
Following this, Theoreo staff will engage in the free administration of the MEDEA test for screening endometrial cancer, the most common cancer of the female reproductive tract in Western populations, for which, until now, no screening system had been available.
The test, which is rapid, painless and noninvasive, requires the drawing of a single drop of blood using a lancet, similar to measuring blood glucose.
Appointment May 11, 2023 at 4 p.m. at the Council Chamber of the City of Baronissi.
You can also make a reservation at: +39 334 1921903 or by email by contacting medical@theoreosrl.com.
11-May-2023
FREE OPENDAY FOR WOMEN'S CANCER PREVENTION, AS PART OF THE CITY OF PONTECAGNANO FAIANO'S "OLTRE l'8 MARZO" EVENT
We are happy to announce that on 03/27/2023 at our office at 57 Lucania Street, Pontecagnano Faiano, there will be an open day with free examinations, entirely dedicated to women's prevention.
They will be carried out free of charge with prior reservation:
âś“ Visit with Dr. Luigi Cremone, a breast surgeon. An appointment for a mammography examination, also free of charge, will also be provided for women who have received doubtful or unfavorable results from the breast evaluation, on a date to be arranged at the office of Diagnostica Cavallo of Drs. Armando and Pierpaolo Cavallo.
âś“ Visit with Dr. Valentina Reina, a medical doctor specializing in Aesthetic Medicine, for the prevention and treatment of skin blemishes and skin damage caused by solar radiation.
âś“ Nutritional counseling with Dr. Chiara D'Antonio, a nutrition biologist, in which an assessment of the patient's physical and nutritional status will be carried out with the aim of identifying any unhealthy eating habits and re-educating or rehabilitating the patient nutritionally and dietarily.
âś“ MEDEA test, an innovative screening system for endometrial cancer, developed by Theoreo srl in collaboration with the G. Pascale Cancer Institute and the University of Salerno. The test consists of taking a single drop of blood by digital puncture. The sample will undergo metabolomic analysis in order to identify patients with the disease early. The above test is dedicated to women over the age of 50.
The event will be sponsored by the Municipality of Pontecagnano Faiano as part of the series "Beyond March 8, Variations on the Theme," in which Theoreo stands at the forefront of offering direct support to the community by taking care of those who have always been its pillars: women.
You can also make reservations by phone: +39 334 1921903 or by email by contacting medical@theoreosrl.com.
We are waiting for you!
Your health, our mission.
01-March-2023
Metabolomics in Public Health: new screening methods for endometrial cancer
Our CEO had a talk at the GYNOCARE COST Action Conference, "Bridging the gap between Research and Cure in Rare Gynaecological Cancers: Where do we stand?" held Feb. 17 and 18 at the University of Campania "Luigi Vanvitelli" in Naples.
The conference was in collaboration with European Network for Gynaecological Rare Cancer research: From Concept to Cure.
The invited international speakers,shared insights on recent developments in gynecological rare cancers, focusing on:
- Basic and translational research: present and future
- Clinical trials: designing cures
- Difficult diagnosis: from the classical method to digital pathology
- Pharma-Biotech: the challenges of the 21st century
Theoreo's talk was titled "Development and Validation of a Serum Metabolomic Signature for Endometrial Cancer Screening in Postmenopausal Women."
Local organizers are Professor Francesca Pentimalli of LUM Giuseppe Degennaro University, Professor Antonio Giordano of the University of Siena, Professor Maurizio Guida of the University of Naples Federico II, Professor Renato Franco of the University of Campania "Luigi Vanvitelli"
18-February-2023
Metabolomics in Public Health: new screening methods for endometrial cancer
On December 16, 2022, Theoreo in collaboration with prestigious research and treatment institutions will organize the first "Metabolomics in Public Health" conference. This first year has been dedicated to new methods for screening endometrial cancer.
Endometrial cancer represents the most common neoplasm of the female reproductive system, with more than 88,000 diagnoses per year in Europe. Although the prognosis is closely linked to early diagnosis, there is currently no mass screening for early detection of this cancer.
To effectively combat this disease, Theoreo and Hosmotic, two Campania-based companies engaged in scientific research in biotechnology, have joined efforts with authoritative Campania university and clinical institutions including the University of Salerno, the University of Naples Federico II, the IRCCS fondazione "G. Pascale" and the Avellino section of LILT (Lega Italiana per la Lotta ai Tumori) to create a tool that can be used as a secondary prevention tool, thus for population screening.
The free event was attended by numerous experts in the field and was accredited for CME credits for physicians, biologists and pharmacists, chemists and physicists.
At the end a benefit concert offered by AFI (Asoociazione Flautisti Italiani), the proceeds of which were donated to the assozioen ACTO Campania (Association Against Ovarian Cancer)
16-December-2022
NEW RESEARCH LABORATORY INAUGURATED
Today we inaugurated the new laboratory of Theoreo where we will converge all our research activities.
A new reality on the territory of Pontecagnano and the Salernitano area (South Italy). A unique center, thanks to which we have the ambition to create a place of excellence in Translational Medicine in the South, in Italy and internationally.
4-October-2022
IV CONGRESS OF THE NORMAMERICAN SOCIETY OF METABOLOMICS (MANA)
The MANA (Metabolomics Association of North America) conference, was held Sept. 16-18.
Our CEO Jacopo Troisi (CEO) and Martina Lombardi (CSO) are located together with Prof. Sean Richards and Prof. Steven Symes (the former teaches Biology, the latter Chemistry at the University of Tennessee, Chattanooga) represented Theoreo at this important scientific event.
They presented the results of the latest validation of the Endometrial Carcinoma Screening Test (Medea Project), a noninvasive test to diagnose early this cancer that afflicts more and more women worldwide.
In addition, a poster on the GEMMA study, an international project in which we are involved in the analysis of autism spectrum disorders; one on data on the screening test for fetal malformations called "Mama Test"; one on our work about a unified approach to cancer screening by metabolomic profiling; and discussion on hepatic steatosis and its evolution to hepatocarcinoma.
18-September-2022
MAMA TEST VALIDATION FIRST RESULTS PUBLISHED
It is now available online the paper summarizing the results of a long and complex validation trial of the MAMA Test. With support from the New Zealand arm of the SCOPE study led by Prof. Lesley McCowan of Auckalnd University, researchers at Theoreo blindly applied the MAMA Test to a collection of more than 2,000 pregnant women serum samples from New Zealand. The test correctly detected more than 99% of fetal malformations, confirming the MAMA Test as an accurate and noninvasive ally for early prenatal diagnosis.
The results were published in the prestigious journal AJOG - American Journal of Obstetrics and Gynecology. The papeer is freely accessible until 3rd Dec 2022 at this link.
5-September-2022
METABOLOMICS PERSPECTIVES
This is a unique volume written by Prof. Jacopo Troisi with contributions from some of the leading experts in metabolomics.
This book is designed for teaching the fundamentals of metabolomics in order to fill the gap related to the absence of a single, comprehensive text.
The book guides the reader step by step through metabolomics experiments, discussing the main current applications and future prospects of this emerging science.
Therefore, it is a valuable read for both experienced researchers interested in delving into the field and students.
7-July-2022
18TH INTERNATIONAL CONFERENCE OF THE METABOLOMICS SOCIETY
From June 19 to 23, the 18th International Conference of the Metabolomics Society was held at the Valencia Conference Center, where leading figures in metabolomics attended.
The Theoreo team, along with Professors Steven Symes and Sean Richards from the University of Tennessee, took part in the prestigious event.
Prof. Jacopo Troisi, CEO of Theoreo Srl, gave a plenary presentation on the latest results related to the MEDEA project highlighting how metabolomics represents a new and promising screening tool for early detection of endometrial cancer.
Prof. Steven Symes outlined the GEMMA project, an international research project with a multi-omics approach to study the onset of autism spectrum disorders.
Prof. Sean Richards presented the results on a validation study, carried out at 15 weeks of pregnancy, to screen for fetal malformations.
Dr. Martina Lombardi, researcher at Theoreo Srl, illustrated an Ensemble Machine Learning model based on metabolomic profiling for noninvasive multicancer screening.
23-June-2022
III ANNUAL MEETING OF THE GEMMA PROJECT
The third annual meeting of the GEMMA project, held May 19-20 at the EBRIS Foundation, was a valuable opportunity for interdisciplinary exchange that was attended by all partners afferent to the project.
Theoreo was present with an extensive talk, given by Dr. Martina Lombardi, regarding the perspectives of fecal metabolomics in the study and diagnosis of autism spectrum disorders.
The talk received wide interest, demonstrating the continuing commitment of Theoreo researchers to biomedical study.
3-May-2022
OUR CEO IN RANKING OF TOP METABOLOMICS EXPERTS
Our CEO Jacopo Troisi cited in the ranking of top experts in Metabolomics according to the prestigious ExpertScape ranking.
In keeping with Healthy Weight Week (Jan 16-22, 2022), congratulations to Prof. Jacopo Troisi Universita degli Studi di Salerno -- Recognized as an Expertscape Expert in Metabolomics.
21-January-2022
STEROID HORMONE-PRODUCING BACTERIA UNDERLYING RESISTANCE TO ANDROGENIC DEPRIVATION THERAPY IN PROSTATIC CARINOMA
Prostate cancer is often treated with ADT, a therapy that negativly affects the biosynthesis of androgens by reducing the possibility of cancer cells growing. Despite the consolidated effectiveness of this treatment, sometimes some subjects, even many years after the first episode, show a resumption of tumor growth.
The study just published in the prestigious journal Science shows that this recovery may be due to an imbalance in the intestinal microbiota that allows some bacterial species to complete the biosynthesis of testosterone starting from endogenous precursors. These results, if further confirmed, could open to new perspectives for the treatment of this fearful pathology and to a new paradigm in the unknown of the complex interaction between human health and the intestinal microbiome.
Theoreo srl proudly participated in this important study coordinated by the Oncological Research Institute based in Lugano in Switzerland, which lasted more than 3 years and which engaged several Italian, Swiss, American and British researchers.
DETAILS...
7-October-2021
IS IT POSSIBLE A FECAL-ORAL TRANSMISSION OF SARS-COV-2?
What if SARS-CoV-2 isn't transmitted exclusively by air?
Our researchers, who have always been involved in the study of human health protection strategies, have collected the numerous evidences that would seem to suggest a possible fecal-oral transmission of the virus. This scenario opens up new and interesting perspectives both from a therapeutic point of view and for emergency management with a view to containing infections.
The results of this survey have been published, in collaboration with prof. Alessio Fasano, professor of pediatric gastroenterology at Harvard University, in the "World Journal of Gastroenterolology" and are freely available at the link:
"COVID-19 and the gastrointestinal tract: Source of infection or merely a target of the inflammatory process following SARS-CoV-2 infection?"
DETAILS...
16-July-2021
A NEW PATH FOR SCREENING OF BLADDER CANCER
Our researchers, in collaboration with researchers from the University of Tennessee, have taken another small but stubborn step in the fight against cancer by defining a new metabolomic signature for bladder cancer. This opens up new scenarios for understanding the basic mechanisms of neoplastic transformation and for explaining the aggressiveness of some cancers. The results of this study, just published by the journal Applied Science, also indicate an innovative possibility for a population screening system for this disease that affects over 26,000 people a year in Italy alone.
22-March-2021
THEOREO SRL AT THE MICROPHONE OF BIOTECHNOLOGY NEWs
Our CEO guest at the microphones of Biotechnology news. A chat about the present and future of biotechnologies in Italy.
15-March-2021
OUR CEO TEACHER OF THE OMICS SCIENCE COURSE AT THE UNIVERSITY OF SALERNO
Our CEO has obtained the position of lecturer for the exercise mode of the Omics Science course at the Department of Chemistry and Biology "A. Zambelli" of the University of Salerno. The course is active as part of the degree course in Biology.
06-October-2020
OUR CEO TEACHER OF METABOLOMICS AT THE UNIVERSITY OF SANNIO
Our CEO has obtained the position of lecturer for the Metabolomics course at the Department of Science and Technology of the University of Sannio. The course is active within the degree program in Genetic and Molecular Biotechnology.
21-September-2020
INTESTINAL MICROBIOTA: A STOP TO THE DEVELOPMENT OF COLON-RECTUM CANCER DISCOVERED
Our spin-off partnered with Humanitas University in a study that demonstrated, for the first time, that a strain of gut bacteria plays a protective role against the development of colorectal cancer. The results of the research, supported by AIRC - AIRC Foundation for Cancer Research and directed and coordinated by Prof. Maria Rescigno of Humanitas University, were recently published in the journal "Nature Microbiology".
This study lays the foundations to put a stop to the development of colorectal cancer that affects more than 34,000 people every year in Italy alone.
27-January-2020
CONGRESSO NAZIONALE DELLA SOCIETĂ€ ITALIANA DI PSICOPATOLOGIA DELL'ALIMENTAZIONE
Il nostro CEO ha tenuto una presentazione su invito al prestigioso congresso nazionale della SIPA (Società Italiana di Psicopatologia dell'Alimentazione) tenutosi a Torino presso l'aula Magna del Rettorato "Cavallerizza Reale" il 23 e 24 maggio. Il tema di quest'anno è stato: "Stress e disturbi dell'alimnetazione: reti neurali, reti sociali, reti terapeutiche".
L'intervento presentato da Theoreo è stato: "La metabolomica nello studio dell'anoressia nervosa: possibilità e limiti"
24-May-2019 DETTAGLI
"Metabolomics and complex systems in molecular diagnostics" Talk At Salerno University
Our CEO had the talk "Metabolomics and complex systems in molecular diagnostics" at the University of Salerno.
The seminar was held in the classroom P/7 of the Department of Chemistry and Biology
08-May-2019
Theoreo is one of the gemma project's partners
The European Commission has selected the GEMMA project which aims at identifying potential targets able to favor personalized treatment and prevention of Autism Spectrum Disorders. The study will have a budget of € 14.2M.
GEMMA is an innovative scientific research project for the evaluation of interactions between microbiome, metabolome, epigenome and immune response in order to provide new diagnostic and preventive approaches to autism.
01-Jan-2019 DETAILS...
Metabolomic profiles in the progression of non alcoholic fatty liver disease
Dr. Mario Masarone, researcher at the University of Salerno presented at the annual meeting of the American Association for the Study of Liver Diseases (AASLD), held in San Francisco (CA, USA) in November 2018 the study: "Metabolomic profiles in the progression of non alcoholic fatty liver disease". Theoreo is contributing to this exciting study designed by prof. Marcello Persico, Associate Professor of Internal Medicine of the University of Salerno and Director of the Unit of Internal Medicine and Hepatology of P.O. G. Da Procida - AOU Sand Giovanni di Dio e Ruggi D'Aragona, aims to understand the impact of genes-environment relationships in the progression of hepatic steatosis.
In the "details" the link for access to the interview of dr. Masarone at the InfomedicaEducation microphones
22-Nov-2018 DETAILS...
MAMA Test – Presented at the ICBDSR Annual Meeting in Prague
Our researchers had just presented the MAMA Test project at the 45th Annual Meeting of the International Clearinghouse for Birth Defects Surveillance and Research (ICBDSR) in Prague (30th September - 4th October 2018)
30-Sep-2018 DETAILS...
toxic takedown - theoreo's researches on the tennessee university magazine
The University of Tennessee - Chattanooga magazine reports a service on page 17 about the collaboration of our researchers with the prestigious American University.
20-Aug-2018 DETAILS...
MAMA TEST project AWARDED WITH THE INNOVATION AWARd OF THE teratology SOCIETY
The Teratology Society awarded the MAMA Test project with the prestigious "Innovation Award" as part of the annual meeting held in Clearwater Beach, Florida.
Click here to visualize the event's photos
26-Jun-2018 Details...
Femal cancers prevention day
Theoreo will be present on 18 May from 16:00 to 20:00 in Salerno on the waterfront "Trieste" in a day for the prevention of female tumors. At that site it will also be possible to participate in the clinical trial for the validation of the MEDEA Test.
Click here to visualize the event's photos
18-May-2018 Details...
medea-test first paper
The MAMA Test will be presented on 23-27 June at the annual meeting of the Teratology Society in Clearwater, Florida. Our CEO Jacopo Troisi is the only Italian to have won the Travel award for this presentation
30-Apr-2018 Details...
medea-test first paper
It is on line on the site of the "Journal of Proteome Research" the first paper describing the MEDEA-Test
02-Feb-2018 Details...
mama-test first paper (chromosomal anomalies)
It is on line on the site of the "Metabolomics" journal the first paper describing the MAMA-test
11-Oct-2017 Details...
metabolomics summer school 2017
Professors Sean Richards and Steve Symes from the University of Tennessee (USA) are visiting our laboratory to do placental metabolomic experiments on intrauterine growth restriction within the "Metabolomic Summer School 2017"
01-Ago-2017 Details...
METABOLOMICS AND ENDOMETRIAL CANCER: THEOREO-LILT COLLABORATION
The Italian League for Fight against Cancer (LILT) selected and founded our project "assessment of the efficacy of the metabolomic approach in the screening of endometrial cancer", on which we will work in cooperation with the LILT section in Avellino
30-Mar-2017 Details...
mama test clinical validation trial
Now on-line the description of the clinical trial for the validation of the MAMA Test
14-Nov-2016 Details...
MAMA Test - news
Articolo 1 - Articolo 2 - Articolo 3 - Articolo 4 - Articolo 5 - Articolo 6 - Articolo 7 - Articolo 8 - Articolo 9 - Articolo 10 - Articolo 11 - Articolo 12
01-Oct-2016
tHE MEDEA TEST PATENT DESCRIPTION IS NOW AVAILABLE ON LINE
The WIPO (World Intellectual Property Organization) website has just published on-line the description of the Invention on which the MEDEA Test is based.
01-Sep-2016 Details...
Theoreo colloborates on the cd-gemm project
Thanks to the partnership with the EBRIS foundation and with the Mass General Hospital for Children of the Harvard University, Theoreo will be “the last M” of the CD-GEMM (Celiac Disease-Genetic Environmental Microbiome and Metabolomic Study) international study, which aims at comprehending the mechanisms of onset of celiac disease.
06-Feb-2016 Details...
the mama test patent description is now available on-line
The WIPO (World Intellectual Property Organization) website has just published on-line the description of the invention on which the MAMA test is based.
19-Nov-2015
Progettiamo il futuro con L'Europa
The EBRIS Foundation will host the conference “Progettiamo il futuro con l'Europa”
25-May-2015
Theoreo and SuperQuark
Theoreo Srl hosted at its laboratory of metabolomics the shots of a report for the TV programme “SuperQuark”.
04-May-2015